*は責任著者 Corresponding author 


Surgical training in extraperitoneal laparoscopic para‑aortic lymphadenectomy for the treatment of gynecological cancer using a Thiel‑embalmed cadaver.
*S Nagao, M Andou, K Irie, K Kubo, N Ida, T Komiyama, T Kameoka, A Kawaguchi, H Masuyama
Oncology Letters  DOII: 10.3892/ol.2024.14422 


Calcium signals tune AMPK activity and mitochondrial homeostasis in dendrites of developing neurons
A Hatsuda, J Kurisu, K Fujishima, A Kawaguchi, N Ohno, *M Kengaku
Development 150(21), 2023

Truncated radial glia as a common precursor in the late corticogenesis of gyrencephalic mammals
M Bilgic, *Q Wu, T Suetsugu, A Shitamukai, Y Tsunekawa, T Shimogori, M Kadota, O Nishimura, S Kuraku, H Kiyonari, *F Matsuzaki
eLife   DOI: 10.7554/elife.91406.2  2023 

Advanced techniques using in vivo electroporation to study the molecular mechanisms of cerebral development disorders
C Yang, A Shitamukai, *S Yang, *A Kawaguchi
Int J Mol Sci 24(18), 14128, 2023 (review)

神経幹細胞の形態制御と脳発生 Regulation of neural stem cell morphology in brain development
下向敦範、Chen Yang, 川口綾乃
月刊「細胞」55(10)850-853, 2023 (日本語総説)

形態学の視点でとらえる神経前駆細胞の運命決定 Morphological perspectives on the fate determination of neural progenitor cells
岡山医学会雑誌, 135(1)12-17, 2023 (日本語総説)

CD206+ macrophages transventricularly infiltrate the early embryonic cerebral wall to differentiate into microglia.
*Y Hattori, D Kato, F Murayama, S Koike, H Asai,A Yamasaki, Y Naito, A Kawaguchi, H Konishi, M Prinz, T Masuda, H Wake, T Miyata. 
Cell Reports 42 ( 2 )  112092, 2023 


Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation.
S Tang, *T Yonezawa, Y Maeda, M Ono, T Maeba, T Miyoshi, R Momota, Y Tomono, T Oohashi. 
PloS one 16 ( 4 )  e0249909, 2021 

Neuronal delamination and outer radial glia generation in neocortical development. 

*Kawaguchi A., 

 Front. Cell Dev Biol.  2021,8,623573 (review) 



 生化学, 2020, 92(6) 817-821 (日本語総説)

Endfoot regeneration restricts radial glial state and prevents translocation into the outer subventricular zone in early mammalian brain development. 

I Fujita#, A Shitamukai#, F Kusumoto#, S Mase, T Suetsugu, A Omori, K Kato, T Abe, G Shioi, Do Konno, * Matsuzaki. #equal contribution
Nature Cell Biology, 2020, 22:26-37 (理化学研究所 松崎研究室在籍時の業績です)

Transient microglial absence assists postmigratory cortical neurons in proper differentiation.
*Hattori Y, Naito Y, Tsugawa Y, Nonaka S, Wake H, Nagasawa T, Kawaguchi A 

and *Miyata T. 

Nature Communications, 2020, 11:1631

Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma.

S Koshimune, *M Kosaka, N Mizuno, H Yamamoto, T Miyamoto, K Ebisui, S Toyooka & A Ohtsuka. 

BMC Cancer   20 ( 1 )   521,2020


Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development. 

Kawaue T, Shitamukai A, Nagasaka A, Tsunekawa Y, Shinoda T, Saito K, Terada R, Bilgic M, Miyata T, Matsuzaki F, *Kawaguchi A.
Nature Communications, 2019, 10:2780. プレスリリース


Temporal patterning of neocortical progenitor cells: how do they know the right time?
 *Kawaguchi A. 

 Neurosci Res, 2019,138:3-11 (review)


Prolonged Tachycardia with Higher Heart Rate Is Associated with Higher ICU and In-hospital Mortality.
*Hayashi M, Taniguchi A, Kaku R, Fujimoto S, Isoyama S, Manabe S, Yoshida T, Suzuki S, Shimizu K, Morimatsu H, Momota R

Acta medica Okayama   73 ( 2 )   147 - 153,2019


Unripe peach (Prunus persica) extract ameliorates damage from UV irradiation and improved collagen XVIII expression in 3D skin model.
T Yonezawa, *R Momota, H Iwano, S Zhao, T Hakozaki, C Soh, S Sawaki, K Toyama, T Oohash. 
Journal of cosmetic dermatology, 2018

Network of anatomical texts (NAnaTex), an open-source project for visualizing the interaction between anatomical terms.
*R Momota, A Ohtsuka.
Anatomical Science International   93 ( 1 )   149 - 153, 2018 

Conclusive Evidence for OCT4 Transcription in Human Cancer Cell Lines: Possible Role of a Small OCT4-Positive Cancer Cell Population.
T Miyamoto, N Mizuno, *M Kosaka, Y Fujitani, E Ohno, A Ohtsuka.
STEM CELLS   36 ( 9 )   1341 - 1354,2018

Type IV collagen α6 chain is a regulator of keratin 10 in keratinization of oral mucosal epithelium.
Komori T, *Ono M, Hara ES, Ueda J, Nguyen HTT, Nguyen HT, Yonezawa T, Maeba T, Kimura-Ono A, Takarada T, Momota R, Maekawa K, Kuboki T, Oohashi T
Scientific reports 8(1) 2612-2612 2018

Neural progenitor cells undergoing Yap/Tead-mediated enhanced self-renewal from heterotopias more easily in the diencephalon than in the telencephalon. 

Saito K, Kawasoe R, Sasaki H, Kawaguchi A and *Miyata T.  

Neurochem Res, 2018, 43:171-180


Division modes and physical asymmetry in cerebral cortex progenitors.
Delaunay D, Kawaguchi A, *Dehay C, *Matsuzaki F. 
Current Opinion in Neurobiology, 2017,42:75-83 (review)


Differences in the mechanical properties of the developing cerebral cortical proliferative zone between mice and ferrets at both the tissue and single-cell levels.
Nagasaka A, Shinoda T, Kawaue T, Suzuki M, Nagayama K, Matsumoto T, Ueno N, Kawaguchi A and *Miyata T.
Front.Cell Dev. Biol. 2016, 4:139


Cell cycle–arrested cells know the right time.  

 *Kawaguchi A, and *Matsuzaki F. 

Cell Cycle 2016,15:20, 2683-2684 (review)


Cell cycle–independent transitions in temporal identity of mammalian neural progenitor cells. 

Okamoto M, Miyata T, Konno D, Ueda R H, Kasukawa T, Hashimoto M, *Matsuzaki F, and *Kawaguchi A
Nature Communications 2016,7:11349,プレスリリース科研費NEWS, 理研CDBニュース


Interkinetic nuclear migration generates and oppses ventricular-zone crowding: insight into tissue mechanics.  

*Miyata T, Okamoto M, Shinoda T, Kawaguchi A

Front Cell Neurosci, 2015, 8:473 (review)


Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: Visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain. 

Kawaue T, Sagou K, Kiyonari H, Ota K, Okamoto M, Shinoda T, Kawaguchi A, *Miyata T. 

Dev Growth Differ. 2014, 56(4)293-304

Immediate differentiation of neuronal cells from stem/progenitor-like cells in the avian iris tissues. 

T Matsushita, A Fujihara, L Royall, S Kagiwada, M Kosaka, *M Araki. 

Experimental Eye Research, 2014,123:16 - 26 

TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subapical crowding. 

Okamoto M, Namba T, Shinoda T, Kondo T, Watanabe T, Inoue Y, Takeuchi K, Enomoto Y, Ota K, Oda K, Wada Y, Sagou K, Saito K, Sakakibara A, Kawaguchi A, Nakajima K, Adachi T, Fujimori T, Ueda M, Hayashi S, Kaibuchi K,*Miyata T. 

Nature Neuroscience, 2013, 16(11):1556-66

Drosophila type XV/XVIII collagen mutants manifest integrin mediated mitochondrial dysfunction, which is improved by cyclosporin A and losartan
*R Momota, M Narasaki, T Komiyama, I Naito, Y Ninomiya, A Ohtsuka.

Architecture of the subendothelial elastic fibers of small blood vessels and variations in vascular type and size. 

A Shinaoka, R Momota, E Shiratsuchi, M Kosaka, K Kumagishi, R Nakahara, I Naito, *A Ohtsuka. 

Microscopy Microanalysis, 2013, 19 ( 2 ):406 - 414

Abnormalities in the Fiber Composition and Capillary Architecture in the Soleus Muscle of Type 2 Diabetic Goto-Kakizaki Rats
*S Murakami, N Fujita, H Kondo, I Takeda, R Momota, A Ohtsuka, H Fujino.

Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4. 

*K Ohta, A Ito, S Kuriyama, G Lupo, M Kosaka, S Ohnuma, S Nakagawa, H Tanaka. 

Proc. Natl. Acad. Sci.,2011, 108(36):14962-14967

Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution
*R Momota, I Naito, Y Ninomiya, A Ohtsuka
MATRIX BIOLOGY 30(4) 258-266 2011

Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior-born Purkinje cells in the developing mouse lateral cerebellum. 

*Miyata T, Ono Y, Okamoto M, Masaoka M, Sakakibara A, Kawaguchi A,  Hashimoto M, Ogawa M. 

Neural Development , 2010, 5, 23(online).


Lunatic fringe potentiates Notch signaling in the developing brain. 

Kato TM, Kawaguchi A, Kosodo Y, Niwa H, *Matsuzaki F. 

Mol Cell Neurosci. 45, 12-25, 2010


Mechanisms that regulate the number of neurons during mouse neocortical development. 

Miyata T, Kawaguchi D, Kawaguchi A, *Gotoh Y. 

Current Opinion in Neurobiology 20, 22-28, 2010 (review)

Comparison of Capillary Architecture between Slow and Fast Muscles in Rats Using a Confocal Laser Scanning Microscope
S Murakami, H Fujino, I Takeda, R Momota, K Kumagishi, *A Ohtsuka
ACTA MEDICA OKAYAMA 64(1) 11-18 2010

A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression by chondrocytes during endochondral ossification
K Kumagishi, K Nishida, To Yamaai, R Momota, S Miyaki, S Hirohata, I Naito, H Asahara, Y Ninomiya, A Ohtsuka

Single-cell gene profiling defines differential progenitor subclasses in mammalian neurogenesis. 

*Kawaguchi A, Ikawa T, Kasukawa T, Ueda R.H, Kurimoto K, Saitou M, *Matsuzaki F. 

Development 135,3113-3124, 2008 , CDBニュース

Novel variants of Oct-3/4 gene expressed in mouse somatic cells. 

Mizuno N, *Kosaka M

Journal of Biochemical Chemistry 283(45) 30997-31004 2008

Type IV collagen alpha chains of the basement membrane in the rat bronchioalveolar transitional segment
Noriko Hinenoya, Ichiro Naito, Ryusuke Momota, Yoshikazu Sado, Kanae Kumagishi, Yoshifumi Ninomiya, Aiji Ohtsuka

Multipotent cells from mammalian iris pigment epithelium. 

Asami M, Sun G, Yamaguchi M, *Kosaka M

Developmental Biology 304(1) 433-446 2007

Tsukushi inhibits the proliferation of retinal stem/progenitor cells. 

Ohta Kunimasa, Ito Ayako, Kuriyama Sei, Ohnuma Shinichi, Kosaka Mitsuko, Nakagawa Shinichi, Tanaka H. 

Developmental Biology 306(1) 391-391 2007

The differential distribution of type IV collagen alpha chains in the subepithelial basement membrane of the human alimentary canal
Hiroyuki Sato, Ichiro Naito, Ryusuke Momota, Yoshio Naomoto, Tomoki Yamatsuji, Yoshikazu Sado, Yoshifumi Ninomiya, Aiji Ohtsuka

The distributions of type IV collagen alpha chains in basement membranes of human epidermis and skin appendages.
Haruko Hasegawa, Ichiro Naito, Kazuyo Nakano, Ryusuke Momota, Keiichiro Nishida, Takehito Taguchi, Yoshikazu Sado, Yoshifumi Ninomiya, Aiji Ohtsuka

The distribution of type IV collagen alpha chains in the mouse ovary and its correlation with follicular development.
Kazuyo Nakano, Ichiro Naito, Ryusuke Momota, Yoshikazu Sado, Haruko Hasegawa, Yoshifumi Ninomiya, Aiji Ohtsuka

Human erythrocytes possess a cytoplasmic endoskeleton containing beta-actin and neurofilament protein.
Kazutaka Terasawa, Takehito Taguchi, Ryusuke Momota, Ichiro Naito, Takuro Murakami, Aiji Ohtsuka

Developmental ability of cloned embryos from neural stem cells.
Eiji Mizutani, Hiroshi Ohta, Satoshi Kishigami, Nguyen Van Thuan, Takafusa Hikichi, Sayaka Wakayama, Mitsuko Kosaka, Eimei Sato, *Teruhiko Wakayama
REPRODUCTION 132(6) 849-857 2006

Retinal stem/progenitor properties of iris pigment epithelial cells.
GW Sun, M Asami, H Ohta, J Kosaka, *M Kosaka
Developmental Biology 289(1) 243-252 2006

In situ preparation of colloidal iron by microwave irradiation for transmission electron microscopy
S Nakatani, Naito, I, R Momota, N Hinenoya, K Horiuchi, K Nishida, A Ohtsuka
ACTA MEDICA OKAYAMA 60(1) 59-64 2006

Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons. 

*Kawaguchi A, Ogawa M, Saito K, Matsuzaki F, Okano H, Miyata T. 

J Neurosci Res, 78, 784-795, 2004


Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells.  

*Miyata T, Kawaguchi A, Saito K, Kawano M, Muto T, Ogawa M. 

Development 13, 3133-3145, 2004

Adult human retinal pigment epithelial cells capable of differentiating into neurons.
K Amemiya, M Haruta, *M Takahashi, M Kosaka, G Eguchi
Biochem Biophys Res Commun. 316(1) 1-5 2004

Morphological asymmetry in dividing retinal progenitor cells. 

Saito K, Kawaguchi A,  Kashiwagi S, Yasugi S, Ogawa M, *Miyata T. 

 Dev Growth Differ 45, 219-229, 2003


Visualization of cell cycling by an improvement in slice culture methods. 

*Miyata, T., Kawaguchi A,  Saito, K., Kuramochi, H., and Ogawa, M. 

J Neurosci Res 69 (6), 861-868, 2002

Flow cytometric analysis of neural stem cells in the developing and adult mouse brain.  

Murayama, A., Matsuzaki, Y., Kawaguchi A,, Shimazaki, T., and *Okano, H. 

J Neurosci Res 69 (6), 837-847, 2002

Induction ot photoreceptor-specific phenotypes in adult mammalian iris tissue.
Haruta M, Kosaka M, Kanegae Y, Saito I, Inoue T, Kageyama R, Nishida A, Honda Y, *Takahashi M.
Nature Neuroscience 4(12) 1163-1164 2001

Asymmetric inheritance of radial glial fibers by cortical neurons. 

*Miyata, T., Kawaguchi A,, Okano, H., and Ogawa, M. 

Neuron 31 (5), 727-741, 2001


Direct isolation of committed neuronal progenitor cells from transgenic mice co-expressing spectrally-distinct fluorescent proteins regulated by stage-specific neural promoters. 

Sawamoto, K., Yamamoto, A., Kawaguchi A,, Yamaguchi, M., Mori, K., Goldman, S.A. and *Okano, H. 
J Neurosci Res 65 (3), 220-227, 2001


Nestin-EGFP mice: visualization of the self-renewal and multipotency of CNS stem cells. 

Kawaguchi A,  Miyata, T., Sawamoto, K., Takashita, N., Murayama, A., Akamatsu, W., Ogawa, M., Okabe, M., Tano, Y., Goldman, S.A., and *Okano, H. 

Mol Cell Neurosci 17 (2), 259-273, 2001

Differential expression of mouse alpha 5(IV) and alpha 6(IV) collagen genes in epithelial basement membranes
K Saito, Naito, I, T Seki, T Oohashi, E Kimura, R Momota, Y Kishiro, Y Sado, H Yoshioka, Y Ninomiya
JOURNAL OF BIOCHEMISTRY 128(3) 427-434 2000

Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone. 

Roy N., Benraiss A., Wang S., Fraser R., Goodman R., Couldwell W., Nedergaard M., Kawaguchi A, Okano H., *Goldman S.A. 

J Neurosci Res 59 (3), 321-331, 2000


In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus. 

Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A,  Okano H, Nedergaard M, *Goldman SA. 

Nature Medicine 6 (3), 271-277, 2000 

Department of Human Morphology

Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences